3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds

Title: 3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds

Volume: 9 Issue: 6

Author(s): P. Hradil, J. Hlavac, M. Soural, M. Hajduch, M. Kolar and R. Vecerova

Affiliation:

Keywords: Quinolinones, anticancer activity, antibacterial activity, inhibition

Abstract: 2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.

Cite this article as:

Hradil P., Hlavac J., Soural M., Hajduch M., Kolar M. and Vecerova R., 3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds, Mini-Reviews in Medicinal Chemistry 2009; 9 (6) . https://dx.doi.org/10.2174/138955709788452720