Abstract
Inflammatory signaling networks play critical roles in the interpretation and processing of external and internal challenges encountered by living organisms. Consequently, alterations in various inflammatory processes are linked with almost all human diseases, and provide important clues for potential pharmacological intervention. Macrophages and CD4 T helper cells are central modulators within the inflammatory network. Both cells can adopt distinct phenotypes and activation status depending upon their environments. Consequently, they are critically involved in the progression as well as attenuation of various inflammatory processes. This review will highlight recent progress in our understanding toward the complex activation and differentiation of macrophages and CD4 T helper cells and their involvement in inflammation. Furthermore, we will discuss potential cellular and molecular targets within the inflammatory network for pharmacological intervention of human inflammatory diseases.
Keywords: Inflammatory networks, Macrophage activation, T helper cell differentiation, inflammatory diseases
Current Signal Transduction Therapy
Title: Inflammatory Signaling Networks as Targets for Pharmacological Intervention of Chronic Diseases
Volume: 4 Issue: 2
Author(s): Urmila Maitra, Samantha M. Baglin and Liwu Li
Affiliation:
Keywords: Inflammatory networks, Macrophage activation, T helper cell differentiation, inflammatory diseases
Abstract: Inflammatory signaling networks play critical roles in the interpretation and processing of external and internal challenges encountered by living organisms. Consequently, alterations in various inflammatory processes are linked with almost all human diseases, and provide important clues for potential pharmacological intervention. Macrophages and CD4 T helper cells are central modulators within the inflammatory network. Both cells can adopt distinct phenotypes and activation status depending upon their environments. Consequently, they are critically involved in the progression as well as attenuation of various inflammatory processes. This review will highlight recent progress in our understanding toward the complex activation and differentiation of macrophages and CD4 T helper cells and their involvement in inflammation. Furthermore, we will discuss potential cellular and molecular targets within the inflammatory network for pharmacological intervention of human inflammatory diseases.
Export Options
About this article
Cite this article as:
Maitra Urmila, Baglin M. Samantha and Li Liwu, Inflammatory Signaling Networks as Targets for Pharmacological Intervention of Chronic Diseases, Current Signal Transduction Therapy 2009; 4 (2) . https://dx.doi.org/10.2174/157436209788167510
DOI https://dx.doi.org/10.2174/157436209788167510 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cosignaling Molecules Around LIGHT-HVEM-BTLA: From Immune Activation to Therapeutic Targeting
Current Molecular Medicine Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions
Current Pharmaceutical Design Differential Kinetics and Inhibition of Purified Recombinant Tyrosine Kinase 2 (TYK-2) and Its Catalytic Domain JH-1
Protein & Peptide Letters IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression
Current Drug Targets New Analytical Tools for Studying Autoimmune Diseases
Current Pharmaceutical Design Multiple Sclerosis – Established and Novel Therapeutic Approaches
Central Nervous System Agents in Medicinal Chemistry The Anandamide Degradation System as Potential Target for the Treatment of Central Nervous System Related Disorders
Current Medicinal Chemistry - Central Nervous System Agents Picornavirus IRES: Structure Function Relationship
Current Pharmaceutical Design Synthesis and Evaluation of Thiazolidinedione-Coumarin Adducts as Antidiabetic, Anti-Inflammatory and Antioxidant Agents
Letters in Organic Chemistry Interleukin 10 in Antiviral Responses
Current Immunology Reviews (Discontinued) Use of Mesenchymal Stem Cells in Crohn's Disease and Perianal Fistulas: A Narrative Review
Current Stem Cell Research & Therapy Tolerance Induction by Gene Transfer to Lymphocytes
Current Gene Therapy Programmed Symptoms: Disparate Effects United by Purpose
Current Rheumatology Reviews The Interplay between the Gut Immune System and Microbiota in Health and Disease: Nutraceutical Intervention for Restoring Intestinal Homeostasis
Current Pharmaceutical Design Targeting the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in the Central Nervous System: Potential Therapy for Inflammatory Demyelinating Disease?
Current Neurovascular Research Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases
Current Drug Targets Central Nervous System Abnormalities in Fibromyalgia and Chronic Fatigue Syndrome: New Concepts in Treatment
Current Pharmaceutical Design Cannabinoids, Immune System and Cytokine Network
Current Pharmaceutical Design The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders
Mini-Reviews in Medicinal Chemistry Sphingolipid Metabolism and Leukemia: A Potential for Novel Therapeutic Approaches
Anti-Cancer Agents in Medicinal Chemistry