Abstract
Inflammatory signaling networks play critical roles in the interpretation and processing of external and internal challenges encountered by living organisms. Consequently, alterations in various inflammatory processes are linked with almost all human diseases, and provide important clues for potential pharmacological intervention. Macrophages and CD4 T helper cells are central modulators within the inflammatory network. Both cells can adopt distinct phenotypes and activation status depending upon their environments. Consequently, they are critically involved in the progression as well as attenuation of various inflammatory processes. This review will highlight recent progress in our understanding toward the complex activation and differentiation of macrophages and CD4 T helper cells and their involvement in inflammation. Furthermore, we will discuss potential cellular and molecular targets within the inflammatory network for pharmacological intervention of human inflammatory diseases.
Keywords: Inflammatory networks, Macrophage activation, T helper cell differentiation, inflammatory diseases
Current Signal Transduction Therapy
Title: Inflammatory Signaling Networks as Targets for Pharmacological Intervention of Chronic Diseases
Volume: 4 Issue: 2
Author(s): Urmila Maitra, Samantha M. Baglin and Liwu Li
Affiliation:
Keywords: Inflammatory networks, Macrophage activation, T helper cell differentiation, inflammatory diseases
Abstract: Inflammatory signaling networks play critical roles in the interpretation and processing of external and internal challenges encountered by living organisms. Consequently, alterations in various inflammatory processes are linked with almost all human diseases, and provide important clues for potential pharmacological intervention. Macrophages and CD4 T helper cells are central modulators within the inflammatory network. Both cells can adopt distinct phenotypes and activation status depending upon their environments. Consequently, they are critically involved in the progression as well as attenuation of various inflammatory processes. This review will highlight recent progress in our understanding toward the complex activation and differentiation of macrophages and CD4 T helper cells and their involvement in inflammation. Furthermore, we will discuss potential cellular and molecular targets within the inflammatory network for pharmacological intervention of human inflammatory diseases.
Export Options
About this article
Cite this article as:
Maitra Urmila, Baglin M. Samantha and Li Liwu, Inflammatory Signaling Networks as Targets for Pharmacological Intervention of Chronic Diseases, Current Signal Transduction Therapy 2009; 4 (2) . https://dx.doi.org/10.2174/157436209788167510
DOI https://dx.doi.org/10.2174/157436209788167510 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
NF-κB, a Potential Therapeutic Target for the Treatment of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Therapeutic Approach for Neuronal Disease by Regulating Reninangiotensin System
Current Hypertension Reviews ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders
Current Drug Targets Molecular Imaging with Small Animal PET/CT
Current Medical Imaging Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy
Current Pharmaceutical Design Tuning Immune Suppression in Systemic Autoimmunity with Self-Derived Peptides
Inflammation & Allergy - Drug Targets (Discontinued) The Interplay between the Gut Immune System and Microbiota in Health and Disease: Nutraceutical Intervention for Restoring Intestinal Homeostasis
Current Pharmaceutical Design Applications of Umbilical Cord Derived Mesenchymal Stem Cells in Autoimmune and Immunological Disorders: From Literature to Clinical Practice
Current Stem Cell Research & Therapy Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Immunopathological Aspects of Mycoplasma pneumoniae Infection
Current Pediatric Reviews Plasticity of Neuroendocrine-Immune Interactions During Ontogeny: Role of Perinatal Programming in Pathogenesis of Inflammation and Stress- Related Diseases in Adults
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Naturally Arising CD25+CD4+ Regulatory T Cells in Maintaining Immunologic Self-Tolerance and Preventing Autoimmune Disease
Current Molecular Medicine Graphical Abstracts
Current Neuropharmacology Dehydroepiandrosterone (DHEA): A Steroid with Multiple Effects. Is there Any Possible Option in the Treatment of Critical illness?
Current Medicinal Chemistry Physiological and Pathological Functions of Acid-Sensing Ion Channels in the Central Nervous System
Current Drug Targets Metabolic Changes in Autoimmune Diseases
Current Drug Discovery Technologies Role of the α7 Nicotinic Acetylcholine Receptor and RIC-3 in the Cholinergic Anti-inflammatory Pathway
Central Nervous System Agents in Medicinal Chemistry Editorial (Thematic Issue: GABAergic Modulation as Treatment Strategy: Consideration of Several Diseases)
Current Pharmaceutical Design Chemotherapeutic Properties of n-3 Polyunsaturated Fatty Acids - Old Concepts and New Insights
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Biological Activities, Mechanisms of Action and Biomedical Prospect of the Antitumor Ether Phospholipid ET-18-OCH3 (Edelfosine), A Proapoptotic Agent in Tumor Cells
Current Drug Metabolism