Effects of Magnetic Stimulation on Oxidative Stress and Skeletal Muscle Regeneration Induced by Mepivacaine in Rat

Title: Effects of Magnetic Stimulation on Oxidative Stress and Skeletal Muscle Regeneration Induced by Mepivacaine in Rat

Volume: 5 Issue: 1

Author(s): I. Jimena, I. Tasset, R. Lopez-Martos, A. J. Rubio, E. Luque, P. Montilla, J. Pena and I. Tunez

Affiliation:

Keywords: Magnetic stimulation, total nitrite, muscle fiber regeneration, reactive oxygen species

Abstract: We investigated the effect of magnetic field stimulation (MS) on oxidative damage and skeletal muscle injury prompted by mepivacaine injection in the anterior tibial muscle of Wistar rats. The effects of mepivacaine and MS on oxidative stress were evaluated by lipid peroxidation, GSH levels and catalase activity. Muscle regeneration was analyzed by haematoxylin-eosin stained, NADH-TR histochemical reaction, desmin immunostaining as well as by morphometric parameters such as fibers density and fiber area were evaluated. Our data revealed that mepivacaine induced oxidative stress, that MS prevents the harmful effects induced by mepivacaine and that it facilitates the regeneration process of skeletal muscle. In conclusion, the results show the ability of MS to modify skeletal muscle response to mepivacaine.

Cite this article as:

Jimena I., Tasset I., Lopez-Martos R., Rubio J. A., Luque E., Montilla P., Pena J. and Tunez I., Effects of Magnetic Stimulation on Oxidative Stress and Skeletal Muscle Regeneration Induced by Mepivacaine in Rat, Medicinal Chemistry 2009; 5 (1) . https://dx.doi.org/10.2174/157340609787049217