Synthesis and Antitumor Activity of Novel 4-Chloro-3-Arylmaleimide Derivatives

Title: Synthesis and Antitumor Activity of Novel 4-Chloro-3-Arylmaleimide Derivatives

Volume: 6 Issue: 1

Author(s): Guiqing Xu, Qiaojun He, Bo Yang and Yongzhou Hu

Affiliation:

Keywords: 4-chloro-3-arylmaleimide, Synthesis, Antitumor activity

Abstract: A novel series of 4-chloro-3-arylmaleimide derivatives have been synthesized and evaluated for their cytotoxicity in vitro against human leukemia cell line and four human solid cancer cell lines. Most compounds showed high or mediate activity against the cancer cell lines when compared with bisindolylmaleimide. Among them, 4b is the most promising compound.

Cite this article as:

Xu Guiqing, He Qiaojun, Yang Bo and Hu Yongzhou, Synthesis and Antitumor Activity of Novel 4-Chloro-3-Arylmaleimide Derivatives, Letters in Drug Design & Discovery 2009; 6 (1) . https://dx.doi.org/10.2174/157018009787158490

DOI https://dx.doi.org/10.2174/157018009787158490	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X