Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases

Author(s): Chi-Ming Hai

Volume 8, Issue 12, 2008

Page: [1209 - 1213] Pages: 5

DOI: 10.2174/138955708786140981

Price: $65

Abstract

Caldesmon is a negative regulator of cell proliferation, migration, and metalloproteinase release. Caldesmon function is regulated by multiple kinases, targeting multiple phosphorylation sites. Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases.

Keywords: Actin, atherosclerosis, caldesmon, calmodulin, restenosis, vascular smooth muscle


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy