An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst

Title: An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst

Volume: 5 Issue: 7

Author(s): Ji-Tai Li, Xin-Li Zhai, Zhi-Ping Lin and Xiao-Hui Zhang

Affiliation:

Keywords: 7,11-Diarylspiro[5.5]undecane-1, 9-dione, synthesis, ultrasound irradiation, Michael condensation, phase-transfer catalysis

Abstract: Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5- bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.

Cite this article as:

Li Ji-Tai, Zhai Xin-Li, Lin Zhi-Ping and Zhang Xiao-Hui, An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982103