Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom

Title: Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom

Volume: 15 Issue: 9

Author(s): Mario T. Murakami, Marco R. Lourenzoni, Emerson Z. Arruda, Marcelo A. Tomaz, Magno M. Vicoti, Jose R. B. Abrego, Paulo A. Melo and Raghuvir K. Arni

Affiliation:

Keywords: Phospholipases A2, suramin, pharmacological activities, structural studies

Abstract: Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.

Cite this article as:

Murakami T. Mario, Lourenzoni R. Marco, Arruda Z. Emerson, Tomaz A. Marcelo, Vicoti M. Magno, Abrego R. B. Jose, Melo A. Paulo and Arni K. Raghuvir, Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom, Protein & Peptide Letters 2008; 15 (9) . https://dx.doi.org/10.2174/092986608785849245