Abstract
Genistein, a major component of soybean isoflavone, has been shown to inhibit cell proliferation and enhance apoptosis in cancer cells. Accumulating bodies of evidence suggest that genistein is expected to synergistically promote the anti-proliferative effects of chemotherapeutic agents on neoplasia without toxicity. At molecular biological levels, a wide array of genistein targets has been characterized so far. These include transcription factors such as NF-kappaB and several signaling pathways. Genistein also reduces oxidative stress. When all the information is taken together, genistein could be applied together with chemotherapeutic agents to cure neurodegenerative disease as well as neoplasia. In this review, recent findings, of molecular actions of genistein, especially during the past three years, have been summarized to explore the potential therapeutic usage of genistein for human disease.
Keywords: Genistein, NF-kappaB, apoptosis, signal transduction, oxidative stress, chemotherapeutics
Current Signal Transduction Therapy
Title: Signal Transduction Pathway Regulated by Genistein and its Therapeutic Use
Volume: 3 Issue: 3
Author(s): Kenichi Yoshida
Affiliation:
Keywords: Genistein, NF-kappaB, apoptosis, signal transduction, oxidative stress, chemotherapeutics
Abstract: Genistein, a major component of soybean isoflavone, has been shown to inhibit cell proliferation and enhance apoptosis in cancer cells. Accumulating bodies of evidence suggest that genistein is expected to synergistically promote the anti-proliferative effects of chemotherapeutic agents on neoplasia without toxicity. At molecular biological levels, a wide array of genistein targets has been characterized so far. These include transcription factors such as NF-kappaB and several signaling pathways. Genistein also reduces oxidative stress. When all the information is taken together, genistein could be applied together with chemotherapeutic agents to cure neurodegenerative disease as well as neoplasia. In this review, recent findings, of molecular actions of genistein, especially during the past three years, have been summarized to explore the potential therapeutic usage of genistein for human disease.
Export Options
About this article
Cite this article as:
Yoshida Kenichi, Signal Transduction Pathway Regulated by Genistein and its Therapeutic Use, Current Signal Transduction Therapy 2008; 3 (3) . https://dx.doi.org/10.2174/157436208785699703
DOI https://dx.doi.org/10.2174/157436208785699703 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Rat Resources in Biomedical Research
Current Pharmaceutical Biotechnology Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review
Mini-Reviews in Medicinal Chemistry Current Therapeutic Paradigms in Glioblastoma
Reviews on Recent Clinical Trials Kinase Inhibitors with Redox and Anti-inflammatory Activities
Current Topics in Medicinal Chemistry Editorial: Targeting Neuregulin1 and HER Receptor Tyrosine Kinases for Therapy of Breast Cancer and Heart Failure
Current Pharmaceutical Design Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy
Current Pharmaceutical Design Antifertility Activity of Lac (Laccifer lacca Kerr.) in Female Wistar Rat Model
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Investigation of the Antiproliferative Action of the Quinoline Alkaloids Kokusaginine and Skimmianine on Human Cell Lines
Current Signal Transduction Therapy Antioxidant, Anti-Inflammatory and Anticancer Activities of the Methanolic Extract of Thottea siliquosa: An <i>In Vitro</i> and <i>In Silico</i> Study
Recent Patents on Anti-Cancer Drug Discovery Regulation of Multidrug Resistance by Pro-Inflammatory Cytokines
Current Cancer Drug Targets The Passive Targeting and the Cytotoxicity of Intravenous 10-HCPT Nanosuspension
Current Nanoscience Nutrient-By-Genotype Interactions and Personalized Diet: What Can We Learn From Drosophila and Evolutionary Biology?
Current Pharmacogenomics and Personalized Medicine HGF and RhoGTPases in Cancer Cell Motility
Current Signal Transduction Therapy Advances in the Development of Anticancer HSP-based Vaccines
Current Medicinal Chemistry Anti-Angiogenesis and RGD-Containing Snake Venom Disintegrins
Current Pharmaceutical Design Nucleic Acid-based Technologies in Therapy of Malignant Gliomas
Current Pharmaceutical Biotechnology Bisphosphonates and Breast Cancer Prevention
Anti-Cancer Agents in Medicinal Chemistry Ribonucleotide Reductase: A Mechanistic Portrait of Substrate Analogues Inhibitors
Current Medicinal Chemistry Role of Colloidal Drug Delivery Carriers in Taxane-mediated Chemotherapy: A Review
Current Pharmaceutical Design Pre-B Cell Colony Enhancing Factor/NAMPT/Visfatin in Inflammation and Obesity- Related Disorders
Current Pharmaceutical Design