Dopamine D5 Receptors: A Challenge to Medicinal Chemists

Title: Dopamine D5 Receptors: A Challenge to Medicinal Chemists

Volume: 8 Issue: 10

Author(s): G. Giorgioni, A. Piergentili, S. Ruggieri and W. Quaglia

Affiliation:

Keywords: Dopamine receptor ligands, D1 subtype, D5 subtype, structure-activity relationship (SAR), pharmacophore

Abstract: Due to the lack of highly selective dopamine D1 or D5 receptor ligands, only few data about activation or blocking of these receptor subtypes are available. The present review collects the available information about molecules with notable affinity for D5 receptor subtype with the purpose to help the researchers to design novel D5 selective ligands, whose discovery may enrich the knowledge about the physiological function of such a receptor, provide information about its topography, as well as lead to novel potential therapeutic tools.

Cite this article as:

Giorgioni G., Piergentili A., Ruggieri S. and Quaglia W., Dopamine D5 Receptors: A Challenge to Medicinal Chemists, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740661