Generic placeholder image

Recent Patents on Anti-Infective Drug Discovery

Editor-in-Chief

ISSN (Print): 1574-891X
ISSN (Online): 2212-4071

NS5A - From Obscurity to New Target for HCV Therapy

Author(s): Uli Schmitz and Seng-Lai Tan

Volume 3, Issue 2, 2008

Page: [77 - 92] Pages: 16

DOI: 10.2174/157489108784746597

Price: $65

Abstract

The hepatitis C virus (HCV) non-structural 5A (NS5A) protein is essential for viral RNA replication and may play a role in subverting host intracellular signaling pathways. Although no intrinsic enzymatic activity has been ascribed to NS5A, this proline-rich hydrophilic phosphoprotein is likely to exert its functions by interacting with viral and cellular factors. Recent studies using the HCV replicon cell culture system as a model for HCV RNA replication as well as for high-throughput screening of pharmacological inhibitors have revealed blockade of NS5A as a promising therapeutic strategy for the treatment of HCV. This review will summarize our progress in understanding the role of NS5A in HCV RNA replication and will introduce the most recent patents on inhibitors of NS5A.

Keywords: HCV, NS5A, antivirals, HCV inhibitors, hyperphosphorylation

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy