Is Plasma Amyloid-β a Reliable Biomarker for Alzheimers Disease?

Title: Is Plasma Amyloid-β a Reliable Biomarker for Alzheimers Disease?

Volume: 3 Issue: 2

Author(s): Henrik Zetterberg

Affiliation:

Keywords: Plasma, Amyloid beta, Alzheimer's disease, Mild cognitive impairment, Biomarker

Abstract: Over the past decade, a tremendous amount of consistent data have accumulated showing reduced levels of the 42 amino acid isoform of amyloid-β (Aβ42) in cerebrospinal fluid (CSF) from patients with mature as well as incipient Alzheimers disease (AD). However, as CSF analyses necessitate a spinal tap, which some consider hard to implement in the clinical routine and in clinical trials, there is a strong interest in the possible association of Aβ levels in plasma with AD. This review provides an update on the current status of research on plasma Aβ as a biomarker for AD in the context of recent patents in the field.

Cite this article as:

Zetterberg Henrik, Is Plasma Amyloid-β a Reliable Biomarker for Alzheimers Disease?, Recent Patents on CNS Drug Discovery (Discontinued) 2008; 3 (2) . https://dx.doi.org/10.2174/157488908784534595