Synthesis and Anticancer Activity of Phthalimido and Naphthalimido Substituted Dihydropyrimidone Conjugates

Title: Synthesis and Anticancer Activity of Phthalimido and Naphthalimido Substituted Dihydropyrimidone Conjugates

Volume: 5 Issue: 4

Author(s): Ahmed Kamal, S. F. Adil, Jaki R. Tamboli, B. Siddardha and U. S.N. Murthy

Affiliation:

Keywords: Biginelli reaction, One-pot synthesis, Dihydropyrimidinones, Phthalimide, Naphthalimide, Anticancer

Abstract: A series of phthalimido-dihydropyrimidones (19a-l) and naphthalimido-dihydropyrimidones (23a-l) have been synthesized and some representative compounds have been evaluated for their in vitro anticancer activity. Compounds 19d, 19f and 19j are selectively active against leukemia while showing moderate activity against broad spectrum of cancer cell lines. The compounds (19a-l) and (23a-l) also have been evaluated for their antibacterial and antifungal activities.

Cite this article as:

Kamal Ahmed, Adil F. S., Tamboli R. Jaki, Siddardha B. and Murthy S.N. U., Synthesis and Anticancer Activity of Phthalimido and Naphthalimido Substituted Dihydropyrimidone Conjugates, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619933