Abstract
A series of Schiff bases 1-20 was synthesised by the condensation of isatin with primary aromatic amines. All the synthesized compounds 1-20 were randomly screened for their in vitro anti-leishmanial potential. Compounds 2, 5, 7, 10, 13 and 16 also showed good anti-leishmanial activities having IC50 value 4.77 ± 0.1, 6.85 ± 0.21, 1.84 ± 0.2, 2.44 ± 0.03, 4.70 ± 0.04 and 8.58 ± 0.04 μg/mL, respectively. Remaining compounds with IC50 values grater than 10.00 μg/mL were considered to be inactive. Their activity was compared with standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.1 μg/mL). The structures of all the synthesised compounds were deduced by spectroscopic analysis.
Letters in Drug Design & Discovery
Title: Schiff Bases of Istain: Potential Anti-Leishmanial Agents
Volume: 5 Issue: 4
Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Samreen, Shahnaz Perveen and Muhammad Iqbal Choudhary
Affiliation:
Abstract: A series of Schiff bases 1-20 was synthesised by the condensation of isatin with primary aromatic amines. All the synthesized compounds 1-20 were randomly screened for their in vitro anti-leishmanial potential. Compounds 2, 5, 7, 10, 13 and 16 also showed good anti-leishmanial activities having IC50 value 4.77 ± 0.1, 6.85 ± 0.21, 1.84 ± 0.2, 2.44 ± 0.03, 4.70 ± 0.04 and 8.58 ± 0.04 μg/mL, respectively. Remaining compounds with IC50 values grater than 10.00 μg/mL were considered to be inactive. Their activity was compared with standard drugs, amphotericin B (IC50 = 0.12 ± 0.41 μg/mL) and pentamidine (IC50 = 2.56 ± 0.1 μg/mL). The structures of all the synthesised compounds were deduced by spectroscopic analysis.
Export Options
About this article
Cite this article as:
Khan Mohammed Khalid, Mughal Rasool Uzma, Samreen , Perveen Shahnaz and Choudhary Iqbal Muhammad, Schiff Bases of Istain: Potential Anti-Leishmanial Agents, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619915
DOI https://dx.doi.org/10.2174/157018008784619915 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Multiple Functions of Mammalian Germinal Center Kinases
Current Chemical Biology Monoclonal Antibodies in the Treatment of Leukemia
Current Molecular Medicine New Drugs for Epidural Analgesia
Current Drug Targets Oxidative-Nitrosative Stress In Hypertension
Current Vascular Pharmacology Next Generation Sequencing in the Management of Leptomeningeal Metastases of Non-Small Cell Lung Cancer: A Case Report and Literature Review
Recent Patents on Anti-Cancer Drug Discovery Brain Excitatory/Inhibitory Circuits Cross-Talking with Chromogranin A During Hypertensive and Hibernating States
Current Medicinal Chemistry Metformin Beyond Diabetes: New Life for an Old Drug
Current Diabetes Reviews Antiplatelet and Anticoagulation Strategies in the Prevention and Treatment of Ischemic Stroke
Current Pharmaceutical Design An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities
Mini-Reviews in Medicinal Chemistry Modulators of Voltage-Dependent Calcium Channels for the Treatment of Nervous System Diseases
Recent Patents on CNS Drug Discovery (Discontinued) A Novel Therapeutic Strategy Against Vascular Disorders with Chymase Inhibitor
Current Vascular Pharmacology Therapeutic Use of Nitric Oxide Scavengers in Shock and Sepsis
Current Pharmaceutical Design Snake Venom: From Deadly Toxins to Life-saving Therapeutics
Current Medicinal Chemistry A Critical Review of Atypical Antipsychotic Utilization: Comparing Monotherapy with Polypharmacy and Augmentation
Current Medicinal Chemistry Role of Heme Oxygenase-1 in Cardiovascular Function
Current Pharmaceutical Design Association Between Heart Rate Variability and Parkinson’s Disease: A Meta-analysis
Current Pharmaceutical Design Therapeutic Effects of Renal Denervation on Renal Failure
Current Neurovascular Research Mexiletine Metabolites: A Review
Current Medicinal Chemistry Gender Differences in Hemodynamic Regulation and Cardiovascular Adaptations to Dynamic Exercise
Current Cardiology Reviews Renal Microcirculation and Calcium Channel Subtypes
Current Hypertension Reviews