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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Activity of New Tricyclic Purine Derivatives Obtained by Intramolecular N-7 Alkylation

Author(s): Arturene Maria Lino Carmo, Fernanda Gambogi Braga, Marcio Luiz De Paula, Ana Paula Ferreira, Henrique Couto Teixeira, Adilson David da Silva and Elaine Soares Coimbra

Volume 5, Issue 2, 2008

Page: [122 - 126] Pages: 5

DOI: 10.2174/157018008783928535

Price: $65

Abstract

Intramolecular N-7 alkylation of 6-substituted purines gave rise to a new series of tricyclic purine derivatives. The new compounds were evaluated for their cytotoxicity, their antileishmania activity together with their capacity to modulate NO production in macrophages. As a result compound 1 exhibited a modest activity against KB cells. On the other hand 4a was active against Leishmania and it diminished NO production of BCG-induced J774A.1 cells.

Keywords: Purine analogues, Antileishmania, Anticancer, NO production


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