Abstract
This chapter describes the life cycle, general morphology and ultrastructure of the larval and adult stages of Taenia solium, a parasitic flatworm of humans found in underdeveloped countries. Experimental results describing the role of proteins and glycoproteins in the host-parasite relationship, as well as the various strategies the larval stage has developed to evade the host immune responses are analyzed. Characteristics of the tapeworm attachment site in the hamster intestine and the host inflammatory reaction are reviewed. The general morphology and ultrastructure of the experimental tapeworm is described, with emphasis on muscle fiber distribution, the abundance of cytoplasmic glycogen and its association with gap junctions, the development of testis, structure of mature spermatids and vas efferens. Recent descriptions of T. solium actin, myosin and calreticulin components, metabolic steroid pathways, apoptosis and glucose uptake of tapeworms in the hamster model are reviewed.
Keywords: Taenia solium, surface glycoproteins, ultrastructure, tegument, paramyosin, glycogen, myofibrils, gap junction
Current Topics in Medicinal Chemistry
Title: Morphology and Biochemistry of the Pork Tapeworm, Taenia solium
Volume: 8 Issue: 5
Author(s): Kaethe Willms
Affiliation:
Keywords: Taenia solium, surface glycoproteins, ultrastructure, tegument, paramyosin, glycogen, myofibrils, gap junction
Abstract: This chapter describes the life cycle, general morphology and ultrastructure of the larval and adult stages of Taenia solium, a parasitic flatworm of humans found in underdeveloped countries. Experimental results describing the role of proteins and glycoproteins in the host-parasite relationship, as well as the various strategies the larval stage has developed to evade the host immune responses are analyzed. Characteristics of the tapeworm attachment site in the hamster intestine and the host inflammatory reaction are reviewed. The general morphology and ultrastructure of the experimental tapeworm is described, with emphasis on muscle fiber distribution, the abundance of cytoplasmic glycogen and its association with gap junctions, the development of testis, structure of mature spermatids and vas efferens. Recent descriptions of T. solium actin, myosin and calreticulin components, metabolic steroid pathways, apoptosis and glucose uptake of tapeworms in the hamster model are reviewed.
Export Options
About this article
Cite this article as:
Willms Kaethe, Morphology and Biochemistry of the Pork Tapeworm, Taenia solium, Current Topics in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/156802608783790875
DOI https://dx.doi.org/10.2174/156802608783790875 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Targeting Apoptosis Pathway with Natural Terpenoids: Implications for Treatment of Breast and Prostate Cancer
Current Drug Targets Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease
Current Pharmaceutical Design Xanthones as Potential Antioxidants
Current Medicinal Chemistry In Vivo Inhibition of the Estrogen Sulfatase Enzyme and Growth of DMBA-Induced Mammary Tumors by Melatonin
Current Cancer Drug Targets Multi-modal Anti-cancer Activities Provided by a Non-replicating Sendai Virus Envelope
Current Cancer Therapy Reviews Mevalonate Kinase Deficiency: Disclosing the Role of Mevalonate Pathway Modulation in Inflammation
Current Pharmaceutical Design Therapeutic Use of Molecules that Mimic Pathogen Danger Signals
Endocrine, Metabolic & Immune Disorders - Drug Targets Exercise as an Anabolic Stimulus for Bone
Current Pharmaceutical Design Editorial: Atrial Fibrillation after Coronary Surgery: The Need for an Effective Pharmacological Prophylaxis
Current Vascular Pharmacology Beyond the HapMap Genotypic Data: Prospects of Deep Resequencing Projects
Current Bioinformatics Prognostic and Predictive Molecular Markers in Cutaneous Malignant Melanoma: The First Step Toward Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Regulation of Death and Growth Signals at the Plasma Membrane by Sphingomyelin Synthesis: Implications for Hematological Malignancies
Recent Patents on Anti-Cancer Drug Discovery Exploring Polypharmacology in Drug Discovery and Repurposing Using the CANDO Platform
Current Pharmaceutical Design Antibodies Against G-Protein Coupled Receptors: Novel Uses in Screening and Drug Development
Combinatorial Chemistry & High Throughput Screening Preclinical Pharmacokinetics: An Approach Towards Safer and Efficacious Drugs
Current Drug Metabolism A Comparison of the Biological Properties of Small Molecular Weight Agonists and Antagonists of CD200:CD200R Interactions
Medicinal Chemistry The Combination of New Immunotherapy and Radiotherapy: A N ew Potential Treatment for Locally Advanced Non-Small Cell Lung Cancer
Current Clinical Pharmacology C-Type Lectins on Dendritic Cells and Their Interaction with Pathogen-Derived and Endogenous Glycoconjugates
Current Protein & Peptide Science Vesicular Carriers for Skin Drug Delivery: The Pheroid™ Technology
Current Pharmaceutical Design Follicular Cysts: A Single Sign and Different Diseases. A View from Comparative Medicine
Current Pharmaceutical Design