Inhibitory Feature of the Proprotein Convertases Prosegments

Title: Inhibitory Feature of the Proprotein Convertases Prosegments

Volume: 4 Issue: 2

Author(s): Abdel-Majid Khatib, Yannick Bontemps, Marion Lapierre, Geraldine Siegfried and Fabien Calvo

Affiliation:

Keywords: Proprotein convertases, prosegments, inhibitors, processing, maturation, substrates

Abstract: The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.

Cite this article as:

Khatib Abdel-Majid, Bontemps Yannick, Lapierre Marion, Siegfried Geraldine and Calvo Fabien, Inhibitory Feature of the Proprotein Convertases Prosegments, Medicinal Chemistry 2008; 4 (2) . https://dx.doi.org/10.2174/157340608783789176