Glycolipid Stimulators for NKT Cells Bearing Invariant Vα19-Jα33 TCR α Chains

Title: Glycolipid Stimulators for NKT Cells Bearing Invariant Vα19-Jα33 TCR α Chains

Volume: 8 Issue: 3

Author(s): M. Shimamura

Affiliation:

Keywords: Glycolipid, FTY720, NKT cell, invariant TCR, immunomodulator, non-classical MHC class I

Abstract: Attempts have been made to find specific antigens for a novel NKT cell subset bearing invariant Vα19-Jα33 TCR α chains (Vα19 NKT cell). Comprehensive examinations revealed substantial antigenic activity in synthetic α- mannosylceramide (ManCer) that was presented by MR1. Structural modification of the sphingosine moiety of α-ManCer improved antigenic activity to enhance either Th1 or Th2 – promoting cytokine production by Vα19 NKT cells. Such α- ManCer analogues will be useful for developing new therapies as immunomodulators.

Cite this article as:

Shimamura M., Glycolipid Stimulators for NKT Cells Bearing Invariant Vα19-Jα33 TCR α Chains, Mini-Reviews in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/138955708783744119