Abstract
The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.
Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer
Letters in Organic Chemistry
Title: Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines
Volume: 5 Issue: 2
Author(s): Laurent Brard, Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson and Nicholi Vorsa
Affiliation:
Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer
Abstract: The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.
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Cite this article as:
Brard Laurent, Singh K. Rakesh, Lange S. Thilo, Kim K. Kyu, Singh P. Ajay, Hopson Russell and Vorsa Nicholi, Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743966
DOI https://dx.doi.org/10.2174/157017808783743966 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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