Abstract
In this paper we reported the design, synthesis of a series 2-azetidinones with ester or amide group in C-3 sidechain. Their cholesterol absorption inhibition activity was assessed in orally dosed, cholesterol-fed hamsters. It was demonstrated that compound 20c∼d with amid group in C-3 sidechain exhibited high cholesterol absorption inhibition activity.
Keywords: 2-Azetidinones, C-3 sidechain, Cholesterol absorption inhibition activity
Letters in Drug Design & Discovery
Title: Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors
Volume: 5 Issue: 1
Author(s): Huibin Zhang, Yubin Wang, Rui Zhao, Wenlong Huang, Yunman Li and Jinpei Zhou
Affiliation:
Keywords: 2-Azetidinones, C-3 sidechain, Cholesterol absorption inhibition activity
Abstract: In this paper we reported the design, synthesis of a series 2-azetidinones with ester or amide group in C-3 sidechain. Their cholesterol absorption inhibition activity was assessed in orally dosed, cholesterol-fed hamsters. It was demonstrated that compound 20c∼d with amid group in C-3 sidechain exhibited high cholesterol absorption inhibition activity.
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Cite this article as:
Zhang Huibin, Wang Yubin, Zhao Rui, Huang Wenlong, Li Yunman and Zhou Jinpei, Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors, Letters in Drug Design & Discovery 2008; 5 (1) . https://dx.doi.org/10.2174/157018008783406741
DOI https://dx.doi.org/10.2174/157018008783406741 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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