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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Adipocyte as a Novel TSH Target

Author(s): A. Sorisky, T. T. Antunes and A. Gagnon

Volume 8, Issue 1, 2008

Page: [91 - 96] Pages: 6

DOI: 10.2174/138955708783331531

Price: $65

Abstract

Thyroid stimulating hormone (TSH; also known as thyrotropin), binds cognate receptors on the surface of thyrocytes to regulate proliferation and thyroid hormone synthesis. This unidimensional view of TSH is being transformed as new evidence indicates that TSH acts on adipose tissue. Adipocyte inflammatory responses that predispose to cardiovascular disease may occur in thyroid disorders associated with elevated TSH levels.

Keywords: TSH, TSH receptor, adipocyte, interleukin 6, leptin, cardiovascular disease

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