Abstract
This review shortly summarizes the structural and functional properties of ceruloplasmin, the blue copper oxidase of vertebrates. Particular emphasis will be put on the unique copper stoichiometry of ceruloplasmin in comparison to all other multi-copper oxidases, and different hypotheses will be discussed to explain the apparently useless redundancy of type 1 copper ions in the vertebrate oxidase.
Keywords: CERULOPLASMIN, MULTI-COPPER OXIDASE, ascorbate oxidase (C), Coprinus cinereus laccase, ascorbate oxidase, aceruloplasminemia, Copper transport, ferroxidase, multi-copper ferroxidase
Protein & Peptide Letters
Title: Ceruloplasmin, the Unique Multi-Copper Oxidase of Vertebrates
Volume: 8 Issue: 3
Author(s): Giovanni Musci
Affiliation:
Keywords: CERULOPLASMIN, MULTI-COPPER OXIDASE, ascorbate oxidase (C), Coprinus cinereus laccase, ascorbate oxidase, aceruloplasminemia, Copper transport, ferroxidase, multi-copper ferroxidase
Abstract: This review shortly summarizes the structural and functional properties of ceruloplasmin, the blue copper oxidase of vertebrates. Particular emphasis will be put on the unique copper stoichiometry of ceruloplasmin in comparison to all other multi-copper oxidases, and different hypotheses will be discussed to explain the apparently useless redundancy of type 1 copper ions in the vertebrate oxidase.
Export Options
About this article
Cite this article as:
Musci Giovanni, Ceruloplasmin, the Unique Multi-Copper Oxidase of Vertebrates, Protein & Peptide Letters 2001; 8 (3) . https://dx.doi.org/10.2174/0929866013409517
DOI https://dx.doi.org/10.2174/0929866013409517 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Clinical and Biological Relationship between Type II Diabetes Mellitus and Alzheimers Disease
Current Alzheimer Research Association of rs610932 and rs670139 Polymorphisms in the MS4A Gene Cluster with Alzheimer’s Disease: An Updated Meta-analysis
Current Alzheimer Research Fluoxetine Improves Behavioral Performance by Suppressing the Production of Soluble β-Amyloid in APP/PS1 Mice
Current Alzheimer Research Therapeutic Potential of Hepatocyte Growth Factor for Treating Neurological Diseases
Current Drug Therapy GABAA/Bz Receptor Subtypes as Targets for Selective Drugs
Current Medicinal Chemistry Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties
Current Alzheimer Research Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis
Current Neuropharmacology Conference Report: 182nd AAAS Annual Meeting, Washington DC, February 11-15, 2016
CNS & Neurological Disorders - Drug Targets Editorial [Hot topic: Adenosine Receptor Ligands: Where Are We, and Where Are We Going? (Guest Editors: Tiziano Tuccinardi and Adriano Martinelli)]
Current Topics in Medicinal Chemistry Pharmacodynamics of Radiolabelled Anticancer Drugs for Positron Emission Tomography
Current Pharmaceutical Design Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
Current Medicinal Chemistry Current Clinical Applications of In Vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging
Current Medical Imaging Role of Vitamins in Human Health and Nutrition: Sources and Morbidity
Current Nutrition & Food Science Olanzapine Does not Aggrevate Ischemic Neuronal Injury by Focal Cerebral Ischemia: A Dose Related Restriction of the Neuroprotective Effect?
Medicinal Chemistry Inflammation in Ischemic Stroke: Mechanisms, Consequences and Possible Drug Targets
CNS & Neurological Disorders - Drug Targets New Directions for Dementia
Current Neurovascular Research Regression to the Mean: Implications for Clinical Trials of Psychotropic Agents in Dementia
Current Alzheimer Research New Prospectives in the Delivery of Galantamine for Elderly Patients Using the IntelliDrug Intraoral Device: In Vivo Animal Studies
Current Pharmaceutical Design Small-molecule Modulation of HDAC6 Activity: The Propitious Therapeutic Strategy to Vanquish Neurodegenerative Disorders
Current Medicinal Chemistry Chemical Composition, Antioxidant, Alpha-glucosidase Inhibitory, Anticholinesterase and Photoprotective Activities of the Aerial Parts of <i>Schinus molle</i> L.
Current Bioactive Compounds