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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Antihypertensive Drugs that Act on Renin-Angiotensin System with Emphasis in AT1 Antagonists

Author(s): T. Mavromoustakos, V. Apostolopoulos and J. Matsoukas

Volume 1, Issue 2, 2001

Page: [207 - 217] Pages: 11

DOI: 10.2174/1389557013407115

Price: $65

Abstract

Angiotensin II, the primary active hormone in the Renin-Angiotensin System is a major vasoconstrictor implicated in the cause of hypertension. Research efforts have focused in the treatment of disease by blocking its release and more recently by competing its action on AT 1 receptors. This approach generated in the pharmaceutical market, losartan, and other derivatives. To better understand the stereoelectronic requirements that lead to the molecular basis of hypertension the stereochemical features of angiotensin II and its antagonists are studied.

Keywords: Antihypertensive Drugs, Renin-Angiotensin System, AT1 Antagonists, Angiotensin, RENIN ANGIOTENSIN SYSTEM, ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS, RENIN INHIBITORS, Captopril, Enlapril, Remikiren

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