Abstract
The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease.
Keywords: Tau Pathology, Alzheimers Disease, tau hyperphosphorylation
Mini-Reviews in Medicinal Chemistry
Title: Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease
Volume: 2 Issue: 1
Author(s): Felix Hernandez, Filip Lim, Jose J. Lucas, Concepcion Perez-Martin, Franscisco Moreno and Jesus Avila
Affiliation:
Keywords: Tau Pathology, Alzheimers Disease, tau hyperphosphorylation
Abstract: The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease.
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Cite this article as:
Hernandez Felix, Lim Filip, Lucas J. Jose, Perez-Martin Concepcion, Moreno Franscisco and Avila Jesus, Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2002; 2 (1) . https://dx.doi.org/10.2174/1389557023406557
DOI https://dx.doi.org/10.2174/1389557023406557 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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