Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease

Title: Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease

Volume: 2 Issue: 1

Author(s): Felix Hernandez, Filip Lim, Jose J. Lucas, Concepcion Perez-Martin, Franscisco Moreno and Jesus Avila

Affiliation:

Keywords: Tau Pathology, Alzheimers Disease, tau hyperphosphorylation

Abstract: The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease.

Cite this article as:

Hernandez Felix, Lim Filip, Lucas J. Jose, Perez-Martin Concepcion, Moreno Franscisco and Avila Jesus, Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2002; 2 (1) . https://dx.doi.org/10.2174/1389557023406557