Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs

Title: Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs

Volume: 3 Issue: 1

Author(s): Sara Richter and Manlio Palumbo

Affiliation:

Keywords: telomerase, anticancer drug, telomerase inhibitor, htert, mock agents, htert subunit

Abstract: Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site, ii) miscellaneous molecules with unknown mechanism(s) of action, iii) inhibitors of upstream processes of regulation of the hTERT subunit, iiii) immunotherapy against immunogenic hTERT- derived peptides.

Cite this article as:

Richter Sara and Palumbo Manlio, Alternative Approaches to the Discovery and Development of Telomerase- Targeted Anticancer Drugs, Mini-Reviews in Medicinal Chemistry 2003; 3 (1) . https://dx.doi.org/10.2174/1389557033405511