Nucleic Acids as Targets for Antitelomerase Agents

Title: Nucleic Acids as Targets for Antitelomerase Agents

Volume: 3 Issue: 1

Author(s): Patrizia Alberti, Laurent Lacroix, Lionel Guittat, Claude Helene and Jean-Louis Mergny

Affiliation:

Keywords: telomeres, telomerase, cancer, proliferation, g-quadruplex

Abstract: Telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a specialized reverse transcriptase necessary to fully duplicate the chromosomal ends. Telomerase is expressed in tumor cells but not in most somatic cells and thus telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents. In this paper we will present different strategies to inhibit telomerase activity via an interaction with a telomere / telomerase nucleic acid component, with a special emphasis on quadruplex ligands.

Cite this article as:

Alberti Patrizia, Lacroix Laurent, Guittat Lionel, Helene Claude and Mergny Jean-Louis, Nucleic Acids as Targets for Antitelomerase Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (1) . https://dx.doi.org/10.2174/1389557033405485