Abstract
Bilirubin was long considered a useless metabolite of heme catabolism, responsible for the clinical manifestation of jaundice, and potentially toxic in high doses, particularly in neonates. In the past two decades the potent biological properties of bilirubin, particularly as an antioxidant, have been recognised, and this has prompted a number of investigations into this molecule concerning its in vitro and in vivo properties. This review summarises that work, as well as more recent investigations into the potential therapeutic uses of bilirubin.
Keywords: Bilirubin, jaundice, antioxidant
Mini-Reviews in Medicinal Chemistry
Title: Biological Properties and Therapeutic Potential of Bilirubin
Volume: 3 Issue: 3
Author(s): Ross P. McGeary, Alexander J. Szyczew and Istvan Toth
Affiliation:
Keywords: Bilirubin, jaundice, antioxidant
Abstract: Bilirubin was long considered a useless metabolite of heme catabolism, responsible for the clinical manifestation of jaundice, and potentially toxic in high doses, particularly in neonates. In the past two decades the potent biological properties of bilirubin, particularly as an antioxidant, have been recognised, and this has prompted a number of investigations into this molecule concerning its in vitro and in vivo properties. This review summarises that work, as well as more recent investigations into the potential therapeutic uses of bilirubin.
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Cite this article as:
McGeary P. Ross, Szyczew J. Alexander and Toth Istvan, Biological Properties and Therapeutic Potential of Bilirubin, Mini-Reviews in Medicinal Chemistry 2003; 3 (3) . https://dx.doi.org/10.2174/1389557033488213
DOI https://dx.doi.org/10.2174/1389557033488213 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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