Imino-Sugar-Based Nucleosides

Title: Imino-Sugar-Based Nucleosides

Volume: 3 Issue: 5

Author(s): Vern L. Schramm and Peter C. Tyler

Affiliation:

Keywords: imino-sugar-based, iminonucleosides, imino-c-nucleosides

Abstract: Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-Cnucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.

Cite this article as:

Schramm L. Vern and Tyler C. Peter, Imino-Sugar-Based Nucleosides, Current Topics in Medicinal Chemistry 2003; 3 (5) . https://dx.doi.org/10.2174/1568026033452465