Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications

Title: Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications

Volume: 3 Issue: 6

Author(s): Boliang Lou and Kexin Yang

Affiliation:

Keywords: hydroxamic acids, mmps, tace, hdac, hydroxamic acid-based inhibitors

Abstract: A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.

Cite this article as:

Lou Boliang and Yang Kexin, Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487872