Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry

Title: Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry

Volume: 5 Issue: 12

Author(s): R. Fringuelli, L. Milanese and F. Schiaffella

Affiliation:

Keywords: Candida infections, Rheumatoid arthritis, ALDOSE-REDUCTASE INHIBITORS, benzothiazepine nucleus, nimodipine, NEUROPROTECTIVE, anti-tumor

Abstract: 1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.

Cite this article as:

Fringuelli R., Milanese L. and Schiaffella F., Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2005; 5 (12) . https://dx.doi.org/10.2174/138955705774933365