The Role of Cannabinoid System on Immune Modulation: Therapeutic Implications on CNS Inflammation

Title: The Role of Cannabinoid System on Immune Modulation: Therapeutic Implications on CNS Inflammation

Volume: 5 Issue: 7

Author(s): Fernando Correa, Leyre Mestre, Eduardo Molina-Holgado, Angel Arevalo-Martin, Fabian Docagne, Eva Romero, Francisco Molina-Holgado, Jose Borrell and Carmen Guaza

Affiliation:

Keywords: cannabinoids, immune function, neuroinflammation, glial cells, multiple sclerosis

Abstract: There is a growing amount of evidence suggesting that cannabinoids may be neuroprotective in CNS inflammatory conditions. Advances in the understanding of the physiology and pharmacology of the cannabinoid system have increased the interest of cannabinoids as potential therapeutic targets. Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in cells of the immune system, as well as in brain glial cells. In the present review it is summarized the effects of cannabinoids on immune reactivity and on the regulation of neuroinflammatory processes associated with brain disorders with special attention to chronic inflammatory demyelinating diseases such as multiple sclerosis.

Cite this article as:

Correa Fernando, Mestre Leyre, Molina-Holgado Eduardo, Arevalo-Martin Angel, Docagne Fabian, Romero Eva, Molina-Holgado Francisco, Borrell Jose and Guaza Carmen, The Role of Cannabinoid System on Immune Modulation: Therapeutic Implications on CNS Inflammation, Mini-Reviews in Medicinal Chemistry 2005; 5 (7) . https://dx.doi.org/10.2174/1389557054368790