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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

New Perspectives in the Modulation of the Eicosanoid Cascade in Inflammation

Author(s): J. Claria and M. Lopez-Parra

Volume 2, Issue 5, 2005

Page: [391 - 402] Pages: 12

DOI: 10.2174/1570180054405730

Price: $65

Abstract

Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these pathways is key to control inflammation and to promote its resolution.

Keywords: eicosanoids, prostaglandins, leukotrienes, lipoxins, resolvins, inflammation


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