Polypeptide Models to Understand Misfolding and Amyloidogenesis and Their Relevance in Protein Design and Therapeutics

Title: Polypeptide Models to Understand Misfolding and Amyloidogenesis and Their Relevance in Protein Design and Therapeutics

Volume: 12 Issue: 2

Author(s): Jesus Zurdo

Affiliation:

Keywords: protein misfolding and aggregation, protein re-design, protein evolution, amyloid model, amyloid nucleation, amyloid hotspots, polypeptide deposition disorders, amyloidosis

Abstract: The study of amyloid polypeptide models (polypeptides able to generate amyloid structures not necessarily connected with any pathology) provides an excellent tool to increase the understanding of the generic aspects of misfolding and aggregation as well as the details of the mechanism of polypeptide deposition in disease. This knowledge can be integrated and applied to different problems in therapy and biotechnology, and in particular to re-designing bioactive polypeptides (biopharmaceuticals) with improved properties.

Cite this article as:

Zurdo Jesus, Polypeptide Models to Understand Misfolding and Amyloidogenesis and Their Relevance in Protein Design and Therapeutics, Protein & Peptide Letters 2005; 12 (2) . https://dx.doi.org/10.2174/0929866053005791

DOI https://dx.doi.org/10.2174/0929866053005791	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305