Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates

Title: Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates

Volume: 7 Issue: 11

Author(s): Carolina D. Duarte, Eliezer J. Barreiro and Carlos A.M. Fraga

Affiliation:

Keywords: Privileged structures, pharmacophoric point, rational drug design, bioactive N-acylhydrazones derivatives

Abstract: Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications. In the present work, we describe some examples and applications of the usefulness of the privileged structure concept for the structural design of new drug candidates, by discussing the eligibility of such motifs, including the identification of the N-acylhydrazone template as privileged structures.

Cite this article as:

Duarte D. Carolina, Barreiro J. Eliezer and Fraga A.M. Carlos, Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates, Mini-Reviews in Medicinal Chemistry 2007; 7 (11) . https://dx.doi.org/10.2174/138955707782331722