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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Chimeric T Helper-B Cell Peptides Induce Protective Response Against Japanese Encephalitis Virus in Mice

Author(s): S.S. Dewasthaly, G.S. Bhonde, V.Shankarraman, S.M. Biswas, V.M. Ayachit and M.M. Gore

Volume 14, Issue 6, 2007

Page: [543 - 551] Pages: 9

DOI: 10.2174/092986607780990028

Price: $65

Abstract

Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and nonstructural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus.

Keywords: Japanese encephalitis virus, MAb binding peptides, Neutralising antibodies, Chimeric Th-B cell peptides, immunopotentiation, Peptide vaccine


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