Abstract
We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.
Keywords: Lipid Peroxidation, caspase-3, GSH-peroxidase, selective serotonin reuptake inhibitors, Open Field Test
Letters in Drug Design & Discovery
Title: Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression
Volume: 4 Issue: 4
Author(s): Isaac Tunez, Francisco J. Medina, Ignacio Jimena and María del C. Munoz
Affiliation:
Keywords: Lipid Peroxidation, caspase-3, GSH-peroxidase, selective serotonin reuptake inhibitors, Open Field Test
Abstract: We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.
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Tunez Isaac, Medina J. Francisco, Jimena Ignacio and Munoz C. María del, Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620013
DOI https://dx.doi.org/10.2174/157018007784620013 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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