Abstract
A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.
Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery
Letters in Organic Chemistry
Title: Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery
Volume: 3 Issue: 12
Author(s): Xiaochun Wu, Yong Wu, Li Hai and Ying Bao
Affiliation:
Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery
Abstract: A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.
Export Options
About this article
Cite this article as:
Wu Xiaochun, Wu Yong, Hai Li and Bao Ying, Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468004
DOI https://dx.doi.org/10.2174/157017806779468004 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Phytosomes as Biocompatible Carriers of Natural Drugs
Current Medicinal Chemistry Cystatin C, Adipokines and Cardiovascular Risk in HIV Infected Patients
Current HIV Research Transcriptomics
Current Drug Metabolism Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer
Current Drug Delivery In-silico Evidences of Regulatory Roles of WT1 Transcription Factor Binding Sites on the Intervening Sequences of the Human Bcl-2 Gene
Current Bioinformatics Prolonged Adrenal Insufficiency After the Discontinuation of Mitotane Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets Hematopoietic Transplants for Disease Suppression and Cure in Type 1 Diabetes
Current Stem Cell Research & Therapy AMPK as a Potential Anticancer Target - Friend or Foe?
Current Pharmaceutical Design Homocysteine and Folate Therapy in Dialysis Patients
Letters in Drug Design & Discovery Quality by Design (Qbd) Approach to Develop HPLC Method for Estimation of Gliclazide and its Impurity (Gliclazide Impurity A) in Bulk Drug
Current Pharmaceutical Analysis Mango Polyphenols and Its Protective Effects on Diseases Associated to Oxidative Stress
Current Pharmaceutical Biotechnology Control of Mycobacterium tuberculosis Infection by Glutathione
Recent Patents on Anti-Infective Drug Discovery Current Research Issues in the Pharmacokinetics of Antiretroviral Drugs in Children
Current Pediatric Reviews Moving Pictures: Imaging Flow Cytometry for Drug Development
Combinatorial Chemistry & High Throughput Screening Chemistry, Stability and Bioavailability of Resveratrol
Medicinal Chemistry Application of Aptamer-based Hybrid Molecules in Early Diagnosis and Treatment of Diabetes Mellitus: From the Concepts Towards the Future
Current Diabetes Reviews Wnt/beta-Catenin Signaling and Small Molecule Inhibitors
Current Pharmaceutical Design Complex Obesity
Current Pediatric Reviews Graphene Oxide: A Carrier for Pharmaceuticals and a Scaffold for Cell Interactions
Current Topics in Medicinal Chemistry Potent Antihyperglycemic Effect of an Endemic Plant from Morocco (Matthiola Maroccana Coss.) on Normal and Streptozotocin-Induced Diabetic Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets