Abstract
Despite recent advances in understanding the molecular biology of lung carcinoma and the introduction of multiple new chemotherapeutic agents for its treatment, its dismal five-year survival rate ( < 15%) has not changed substantially. The lack of advancements in this area reflects the limited knowledge available concerning the factors that promote oncogenic transformation and proliferation of carcinoma cells in the lung. Tumor growth and invasion are not only the result of malignant transformation, but also depend on environmental influences from their surrounding stroma, local growth factors, and systemic hormones. In particular, the composition of the extracellular matrix is believed to affect malignant behavior in vivo. This document reviews information that implicates the matrix glycoprotein fibronectin in regulation of lung carcinoma cell proliferation, apoptosis and resistance to therapy. Fibronectin is highly expressed in chronic lung disorders where most lung carcinomas are identified. Data available to date indicate that by binding to specific integrin receptors expressed on tumor cells, fibronectin stimulates a number of intracellular signals implicated in the pathobiology of lung carcinogenesis including GTPases, mitogen-activated protein kinases, and the PI3-Kinase/Akt/mTOR pathway. Targeting fibronectin and integrin-mediated signals in tumor cells represents a promising target for the development of effective anti-cancer strategies.
Keywords: Fibronectin, integrin, signaling, human lung carcinoma cells, proliferation, therapy
Current Signal Transduction Therapy
Title: Extracellular Matrix and Aberrant Signaling in Lung Carcinoma: Role of Fibronectin in the Control of Human Lung Carcinoma Cell Growth,Apoptosis and Resistance to Therapy
Volume: 2 Issue: 1
Author(s): Shou Wei Han and Jesse Roman
Affiliation:
Keywords: Fibronectin, integrin, signaling, human lung carcinoma cells, proliferation, therapy
Abstract: Despite recent advances in understanding the molecular biology of lung carcinoma and the introduction of multiple new chemotherapeutic agents for its treatment, its dismal five-year survival rate ( < 15%) has not changed substantially. The lack of advancements in this area reflects the limited knowledge available concerning the factors that promote oncogenic transformation and proliferation of carcinoma cells in the lung. Tumor growth and invasion are not only the result of malignant transformation, but also depend on environmental influences from their surrounding stroma, local growth factors, and systemic hormones. In particular, the composition of the extracellular matrix is believed to affect malignant behavior in vivo. This document reviews information that implicates the matrix glycoprotein fibronectin in regulation of lung carcinoma cell proliferation, apoptosis and resistance to therapy. Fibronectin is highly expressed in chronic lung disorders where most lung carcinomas are identified. Data available to date indicate that by binding to specific integrin receptors expressed on tumor cells, fibronectin stimulates a number of intracellular signals implicated in the pathobiology of lung carcinogenesis including GTPases, mitogen-activated protein kinases, and the PI3-Kinase/Akt/mTOR pathway. Targeting fibronectin and integrin-mediated signals in tumor cells represents a promising target for the development of effective anti-cancer strategies.
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Cite this article as:
Wei Han Shou and Roman Jesse, Extracellular Matrix and Aberrant Signaling in Lung Carcinoma: Role of Fibronectin in the Control of Human Lung Carcinoma Cell Growth,Apoptosis and Resistance to Therapy, Current Signal Transduction Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157436207779317092
DOI https://dx.doi.org/10.2174/157436207779317092 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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