Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis

Title: Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis

Volume: 14 Issue: 1

Author(s): Boris A.M. Pastorino, Christophe N. Peyrefitte, Marc Grandadam, Regine Lebrun, Danielle Moinier, Dominique Rolland, Hugues J. Tolou and Mael Bessaud

Affiliation:

Keywords: Altered specificity, autoproteolysis, flavivirin, NS3, trypsin-like serine protease

Abstract: We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.

Cite this article as:

Pastorino A.M. Boris, Peyrefitte N. Christophe, Grandadam Marc, Lebrun Regine, Moinier Danielle, Rolland Dominique, Tolou J. Hugues and Bessaud Mael, Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/092986607779117146