Abstract
The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.
Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine
Current Topics in Medicinal Chemistry
Title: Selective Agents for Serotonin2C (5-HT2C) Receptor
Volume: 6 Issue: 18
Author(s): Enza Lacivita and Marcello Leopoldo
Affiliation:
Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine
Abstract: The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.
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Cite this article as:
Lacivita Enza and Leopoldo Marcello, Selective Agents for Serotonin2C (5-HT2C) Receptor, Current Topics in Medicinal Chemistry 2006; 6 (18) . https://dx.doi.org/10.2174/156802606778522168
DOI https://dx.doi.org/10.2174/156802606778522168 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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