Abstract
The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has become a bottleneck in the drug development process. In response the pharmaceutical industry is involved in the development of new medium/high-throughput screening capabilities. The aim of this paper is to review some of the available in vitro ADME systems adapted to screening requirements together with the technological approaches which can be linked to medium/high-throughput molecular screening.
Keywords: ADME, metabolism, screening, HTS, mass spectrometry
Mini-Reviews in Medicinal Chemistry
Title: In Vitro ADME Medium/High-Throughput Screening in Drug Preclinical Development
Volume: 6 Issue: 9
Author(s): A. Lahoz, L. Gombau, M. T. Donato, J. V Castell and M. J. Gomez-Lechon
Affiliation:
Keywords: ADME, metabolism, screening, HTS, mass spectrometry
Abstract: The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has become a bottleneck in the drug development process. In response the pharmaceutical industry is involved in the development of new medium/high-throughput screening capabilities. The aim of this paper is to review some of the available in vitro ADME systems adapted to screening requirements together with the technological approaches which can be linked to medium/high-throughput molecular screening.
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Lahoz A., Gombau L., Donato T. M., V Castell J. and Gomez-Lechon J. M., In Vitro ADME Medium/High-Throughput Screening in Drug Preclinical Development, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195153
DOI https://dx.doi.org/10.2174/138955706778195153 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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