Generic placeholder image

Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer

Author(s): Alfonso Catalano and Antonio Procopio

Volume 3, Issue 7, 2006

Page: [459 - 461] Pages: 3

DOI: 10.2174/157018006778194817

Price: $65

Abstract

5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.

Keywords: 5-lipoxygenase, Eicosanoids, Cancer therapy, Lipoxygenase inhibitors


© 2024 Bentham Science Publishers | Privacy Policy