Abstract
Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.
Keywords: Biomarker, colorectal carcinogenesis, DNA repair, gene polymorphism, genetic instability, genetic predisposition, mutations, familial adenomatous polyposis (FAP) syndrome, microsatellite instability, replication, DNA double helix, chromatid, DNA polymerase, pyrimidine dimers, photolyase
Current Molecular Medicine
Title: DNA Repair Mechanisms in Colorectal Carcinogenesis
Volume: 12 Issue: 3
Author(s): C. Michailidi, A. G. Papavassiliou and C. Troungos
Affiliation:
Keywords: Biomarker, colorectal carcinogenesis, DNA repair, gene polymorphism, genetic instability, genetic predisposition, mutations, familial adenomatous polyposis (FAP) syndrome, microsatellite instability, replication, DNA double helix, chromatid, DNA polymerase, pyrimidine dimers, photolyase
Abstract: Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.
Export Options
About this article
Cite this article as:
Michailidi C., G. Papavassiliou A. and Troungos C., DNA Repair Mechanisms in Colorectal Carcinogenesis, Current Molecular Medicine 2012; 12 (3) . https://dx.doi.org/10.2174/156652412799218859
DOI https://dx.doi.org/10.2174/156652412799218859 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Inflammatory and Non-Inflammatory Roles for Toll-Like Receptors in Gastrointestinal Cancer
Current Pharmaceutical Design Vascular Disease and Insulin-Like Growth Factor-1
Vascular Disease Prevention (Discontinued) Recent Advances in Radiopharmaceutical Application of Matched-Pair Radiometals
Current Topics in Medicinal Chemistry Improved Immunogenicity Against a Her2/neu-Derived Peptide by Employment of a Pan HLA DR-Binding Epitope and CpG in a BALB/c Mice Model
Anti-Cancer Agents in Medicinal Chemistry New Trends in Liposome-based Drug Delivery in Colorectal Cancer
Mini-Reviews in Medicinal Chemistry MicroRNAs (miRNAs) in Colorectal Cancer: From Aberrant Expression Towards Therapy
Current Pharmaceutical Design Editorial
Anti-Cancer Agents in Medicinal Chemistry The Effect of Alcohol on Gastrointestinal Motility
Reviews on Recent Clinical Trials The Functions of Histone Modification Enzymes in Cancer
Current Protein & Peptide Science Application of Decoy Oligonucleotides as Novel Therapeutic Strategy: A Contemporary Overview
Current Drug Discovery Technologies Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges
Current Medicinal Chemistry BELFAST Centenarians: A Case of Optimal Cardiovascular Risk?
Current Pharmaceutical Design Proteasome Inhibitors in Cancer Therapy
Current Drug Targets Anticancer Potential of Lepidium Sativum Seeds Aqueous Extract on the Azoxymethane/ Dextran Sulfate Sodium-Induced Colon Cancer In vivo
Current Nutraceuticals From Bacteria to Antineoplastic: Epothilones A Successful History
Anti-Cancer Agents in Medicinal Chemistry Oridonin, a Promising Antitumor Natural Product in the Chemotherapy of Hematological Malignancies
Current Pharmaceutical Biotechnology Systematic Analysis of RNAi Reports Identifies Dismal Commonality at Gene-Level and Reveals an Unprecedented Enrichment in Pooled shRNA Screens
Combinatorial Chemistry & High Throughput Screening Ethnic Differences in Pharmacogenetically Relevant Genes
Current Drug Targets Random Walks on Biomedical Networks
Current Proteomics Practical Aspects in the Use of Biomarkers for the Development of Cancer Vaccines
Current Cancer Therapy Reviews