Abstract
Insulin resistance and the vascular complications of diabetes include activation of the inflammation cascade, endothelial dysfunction, and oxidative stress. The comorbidities of diabetes, namely obesity, insulin resistance, hyperglycemia, hypertension and dyslipidemia collectively aggravate these processes while antihyperglycemic interventions tend to correct them. Increased C-reactive protein, interleukin 6, tumor necrosis factor alpha and especially interstitial cellular adhesion molecule-1, vascular cellular adhesion molecule-1, and E-selectin are associated with cardiovascular and non-cardiovascular complications of both type 1 and type 2 diabetes. We sought to review the clinical implications of the inflammation theory, including the relevance of inflammation markers as predictors of type 2 diabetes in clinical studies, and the potential treatments of diabetes, inferred from the pathophysiology.
Keywords: Inflammation, diabetes mellitus, atherosclerosis, endothelial dysfunction, oxidative stress, adiponectin, hyperglycaemia, hyperlipidaemia, insulin, statins
Current Pharmaceutical Design
Title: Potential Pathogenic Inflammatory Mechanisms of Endothelial Dysfunction Induced by Type 2 Diabetes Mellitus
Volume: 17 Issue: 37
Author(s): Anna-Maria Kampoli, Dimitris Tousoulis, Alexandros Briasoulis, George Latsios, Nikolaos Papageorgiou and Christodoulos Stefanadis
Affiliation:
Keywords: Inflammation, diabetes mellitus, atherosclerosis, endothelial dysfunction, oxidative stress, adiponectin, hyperglycaemia, hyperlipidaemia, insulin, statins
Abstract: Insulin resistance and the vascular complications of diabetes include activation of the inflammation cascade, endothelial dysfunction, and oxidative stress. The comorbidities of diabetes, namely obesity, insulin resistance, hyperglycemia, hypertension and dyslipidemia collectively aggravate these processes while antihyperglycemic interventions tend to correct them. Increased C-reactive protein, interleukin 6, tumor necrosis factor alpha and especially interstitial cellular adhesion molecule-1, vascular cellular adhesion molecule-1, and E-selectin are associated with cardiovascular and non-cardiovascular complications of both type 1 and type 2 diabetes. We sought to review the clinical implications of the inflammation theory, including the relevance of inflammation markers as predictors of type 2 diabetes in clinical studies, and the potential treatments of diabetes, inferred from the pathophysiology.
Export Options
About this article
Cite this article as:
Kampoli Anna-Maria, Tousoulis Dimitris, Briasoulis Alexandros, Latsios George, Papageorgiou Nikolaos and Stefanadis Christodoulos, Potential Pathogenic Inflammatory Mechanisms of Endothelial Dysfunction Induced by Type 2 Diabetes Mellitus, Current Pharmaceutical Design 2011; 17 (37) . https://dx.doi.org/10.2174/138161211798764825
DOI https://dx.doi.org/10.2174/138161211798764825 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Regulation of Vascular Genes by Glucose
Current Pharmaceutical Design Vitamin D Insufficiency and Diabetes Risks
Current Drug Targets The Use of Interferons in Respiratory Diseases
Current Respiratory Medicine Reviews Treatment of Hypertensive Complications in Pregnancy
Current Pharmaceutical Design Maternity Waiting Homes in Rural Districts in Africa; A Cornerstone of Safe Motherhood?
Current Women`s Health Reviews Diverse Mechanisms of AKT Pathway Activation in Human Malignancy
Current Cancer Drug Targets Buxus sempervirens L Improves Streptozotocin-induced Diabetes Mellitus in Rats
Cardiovascular & Hematological Disorders-Drug Targets Editorial (Mini-Thematic Issue: Current Perspectives in Diabetes and Transplantation)
Current Diabetes Reviews A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications
Current Diabetes Reviews Impact of Diabetes Mellitus on Radiological Presentation of Pulmonary Tuberculosis in Otherwise Non-Immunocompromised Patients: A Systematic Review
Current Medical Imaging Rosuvastatin, Pravastatin, and Atorvastatin for the Treatment of Hypercholesterolaemia in HIV-Infected Patients Receiving Protease Inhibitors
Current HIV Research Mutations of Nuclear and Mitochondrial Genomes as Potential Targets for the Treatment of Metabolic Syndrome
Current Pharmaceutical Design Oxytocin and Diabetes Mellitus: A Strong Biochemical Relation. Review
Current Diabetes Reviews Advances in Current Diabetes Proteomics: From the Perspectives of Label- free Quantification and Biomarker Selection
Current Drug Targets Expansion of Umbilical Cord Blood for Clinical Transplantation
Current Stem Cell Research & Therapy Nigella Sativa Improve Redox Homeostasis in Heart and Aorta of Diabetic Rat
Current Nutrition & Food Science Subject Index To Volume 9
Current Medicinal Chemistry Vitamin D Deficiency May Be Associated with a More Rapid Decline in CD4 Cell Count to <350 Cells/µL in Untreated HIV-Infected Adults
Current HIV Research Independent Relationship of Osteocalcin Circulating Levels with Obesity, Type 2 Diabetes, Hypertension, and HDL Cholesterol
Endocrine, Metabolic & Immune Disorders - Drug Targets RAGE, Diabetes, and the Nervous System
Current Molecular Medicine