Flavonoids as Acetylcholinesterase Inhibitors

Title: Flavonoids as Acetylcholinesterase Inhibitors

Volume: 18 Issue: 34

Author(s): I. Uriarte-Pueyo and M. I. Calvo

Affiliation:

Keywords: Acetylcholinesterase inhibitors, Alzheimer's disease, flavonoids, antioxidant activity, structure-activity relationship, natural products, flavones, flavanones, flavonols, isoflavones, chalcones

Abstract: Flavonoids are new promising potential natural compounds for treating Alzheimers disease (AD). Actually most promising drugs for symptomatic treatment of AD are acetylcholinesterase inhibitors (AChEI). Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment. This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Over, all this review refers to 128 flavonoids, which are classified in chemical structure, and summarizes 64 references.

Cite this article as:

Uriarte-Pueyo I. and I. Calvo M., Flavonoids as Acetylcholinesterase Inhibitors, Current Medicinal Chemistry 2011; 18 (34) . https://dx.doi.org/10.2174/092986711798184325