Floating Drug Delivery Systems for Prolonging Gastric Residence Time: A Review

D.      Sathish; S.      Himabindu; Y.      Shravan Kumar; Shayeda; Y.      Madhusudan Rao

doi:10.2174/156720111796642273

Abstract

Oral delivery of the drug is the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations. Recent technological advancements have been made in controlled oral drug delivery systems by overcoming physiological difficulties, such as short gastric residence time and highly variable gastric emptying time. Gastroretentive dosage forms have been designed over the past three decades to overcome these difficulties. Several technical approaches are currently utilized in the prolongation of gastric residence time, including highdensity, swelling and expanding, polymeric mucoadhesive, ion-exchange, raft forming, magnetic and floating drug delivery systems (FDDS), as well as other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

Keywords: Floating drug delivery system (FDDS), Single unit, Multiple units, Hydrodynamically balanced systems (HBS), Microballoons, Gastric residence time (GRT), migrating myoelectric complex (MMC), gastric emptying time (GET), hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), Helicobacter pylori