Self Assembling Polymers as Polymersomes for Drug Delivery

Title: Self Assembling Polymers as Polymersomes for Drug Delivery

Volume: 17 Issue: 1

Author(s): Jay Prakash Jain, Wubeante Yenet Ayen and Neeraj Kumar

Affiliation:

Keywords: Self assembly, polymers, PEG-PLA, (PEG)3-PLA, polymersomes, polymeric vesicles, stimuli responsive, drug delivery, on-togenesis, embryonal (prenatal), Hb (HbE), foetal Hb (HbF), adult Hb (HbA), HbA, ferritin (Fer), hemosiderin, Stores regulator, Dietary regulator, Erythropoetic (Erythroid) regulator

Abstract: Polymersomes are one of the most interesting and versatile architectures among various self assembled systems for drug delivery. The stability and ability to load both hydrophilic and hydrophobic molecules make them excellent candidates to use as drug delivery systems. They demand for certain physicochemical parameters; especially hydrophilic to hydrophobic block ratio of copolymer to form vesicular morphologies. Different amphiphilic copolymers as well as their architectures show differences in the requirement of hydrophilic to hydrophobic block ratio to form polymersomes with various types of morphologies. This review focuses on basic aspects of polymersomes along with a series of copolymers employed for preparation of polymersomes and their potential applications as drug delivery systems.

Cite this article as:

Prakash Jain Jay, Yenet Ayen Wubeante and Kumar Neeraj, Self Assembling Polymers as Polymersomes for Drug Delivery, Current Pharmaceutical Design 2011; 17 (1) . https://dx.doi.org/10.2174/138161211795049822