Abstract
Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.
Keywords: Methamphetamine-induced psychosis, endothelial nitric oxide synthase (NOS3), gene-based case-control association study, endothelial nitric oxide synthase, (NOS3), gene-based case-control association Study, psychiatric disorder, dopaminergic neurotoxicity, schizophrenia, neuronal dysfunction, behavioral abnormality
Current Neuropharmacology
Title: Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese
Volume: 9 Issue: 1
Author(s): Y. Fukuo, N. Iwata, H. Ujike, N. Ozaki, I. Sora, M. Iyo, N. Uchimura, M. Yamada, T. Inada, T. Okochi, T. Tsunoka, T. Okumura, K. Kawashima, Y. Kinoshita, T. Kitajima, M. Ikeda and T. Kishi
Affiliation:
Keywords: Methamphetamine-induced psychosis, endothelial nitric oxide synthase (NOS3), gene-based case-control association study, endothelial nitric oxide synthase, (NOS3), gene-based case-control association Study, psychiatric disorder, dopaminergic neurotoxicity, schizophrenia, neuronal dysfunction, behavioral abnormality
Abstract: Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.
Export Options
About this article
Cite this article as:
Fukuo Y., Iwata N., Ujike H., Ozaki N., Sora I., Iyo M., Uchimura N., Yamada M., Inada T., Okochi T., Tsunoka T., Okumura T., Kawashima K., Kinoshita Y., Kitajima T., Ikeda M. and Kishi T., Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese, Current Neuropharmacology 2011; 9 (1) . https://dx.doi.org/10.2174/157015911795017119
DOI https://dx.doi.org/10.2174/157015911795017119 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Neural and Retinal Characteristics in Relation to Working Memory in Older Adults with Mild Cognitive Impairment
Current Alzheimer Research Anderson-Fabry Disease: A Multiorgan Disease
Current Pharmaceutical Design Evaluation of Audiometric Thresholds and Speech Perception Sentence Test in Adults and Elderly After Cochlear Implantation
Current Aging Science The Role of Therapeutic Drugs on Acquired Mitochondrial Toxicity
Current Drug Metabolism Default Mode Network Connectivity and Related White Matter Disruption in Type 2 Diabetes Mellitus Patients Concurrent with Amnestic Mild Cognitive Impairment
Current Alzheimer Research Cholinergic Treatment of Traumatic Brain Injury
Current Drug Therapy Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential
Current Neuropharmacology Post-stroke Depression Therapy: Where are we now?
Current Neurovascular Research Potential Benefits and Limits of Psychopharmacological Therapies in Pervasive Developmental Disorders
Current Clinical Pharmacology In vivo Proton Magnetic Resonance Spectroscopy and its Applications in Autistic Disorder
Current Molecular Imaging (Discontinued) Radiopharmaceuticals in Neurological and Psychiatric Disorders
Current Clinical Pharmacology Social Neuroeconomics: The Influence of Microbiota in Partner-Choice and Sociality
Current Pharmaceutical Design Ion Channels and Epilepsy
Current Pharmaceutical Design Mechanisms and Treatment of Neuropathic Pain
Central Nervous System Agents in Medicinal Chemistry Neuro-Transmitters in the Central Nervous System & their Implication in Learning and Memory Processes
Current Medicinal Chemistry Mental Training for Cognitive Improvement in Elderly People: What have We Learned from Clinical and Neurophysiologic Studies?
Current Alzheimer Research Myocardial Revascularization for the Elderly: Current Options, Role of Off-pump Coronary Artery Bypass Grafting and Outcomes
Current Cardiology Reviews Late Effects in Survivors of Childhood CNS Tumors: Review of Results From the Two Largest Survivorship Cooperative Groups
Current Cancer Therapy Reviews D-amino Acids as Novel Blood-based Biomarkers
Current Medicinal Chemistry Current Status of Newer Antiinfectives
Recent Patents on Anti-Infective Drug Discovery