Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs

Title: Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs

Volume: 7 Issue: 1

Author(s): Ya-Jun Wang, Yu-Guo Zheng, Ya-Ping Xue, Yuan-Shan Wang and Yin-Chu Shen

Affiliation:

Keywords: Diabetes, Acarbose, Analysis, Liquid chromatography, Capillary electrophoresis, Biosensor, α-glucosidase Inhibitor, Non-Insulin-Dependent Diabetes Mellitus (NIDDM), Refractive Index Detection (RID), Evaporative Light Scattering Detection (ELSD), Normal Phase Liquid Chromatography (NPLC)

Abstract: Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with its strengths and weaknesses. Finally, we analyze the future trends in the acarbose analysis.

Cite this article as:

Wang Ya-Jun, Zheng Yu-Guo, Xue Ya-Ping, Wang Yuan-Shan and Shen Yin-Chu, Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs, Current Pharmaceutical Analysis 2011; 7 (1) . https://dx.doi.org/10.2174/157341211794708721