Abstract
Transient Receptor Potential Vanilloid Type 1 is a prominent “pain” receptor expressed in sensory afferent neurons. TRPV1 on peripheral nerve terminals detects a variety of noxious stimuli generated at sites of injury and inflammation, and in turn, drives the excitation and sensitization of C-fiber neurons. Significantly, TRPV1 is also located on the central terminals of sensory neurons projecting to the spinal cord and brainstem. These TRPV1 channels appear to stimulate the secretion of glutamate. Further, TRPV1 is expressed diffusely in the brain and there is emerging evidence for TRPV1 modulating transmission at various brain synapses. Here we discuss our current understanding of the potential roles for TRPV1 in synaptic transmission.
Keywords: Brain, CNS, pain, presynaptic, spinal cord, TRPV1, Synaptic Transmission, sensory afferent neurons, capsaicin, synaptophysin, noxious stimuli, amygdala, periaqueductal gray, TRPV1 mRNA, tetrodotoxin, vanilloids, eicosanoids, (PKC) activation, PIP2, mEPSCs, TRPV1 channels, PKC stimulation, hippocampal neurons, presynaptic dopamine receptors, EPSC amplitude, endovanilloids, dopaminergic neurons, GABAergic transmission, nociceptive responses, neurohypophysis, capsazepine, PLC signaling
Current Pharmaceutical Biotechnology
Title: TRPV1 and Synaptic Transmission
Volume: 12 Issue: 1
Author(s): Jose A. Matta and Gerard P. Ahern
Affiliation:
Keywords: Brain, CNS, pain, presynaptic, spinal cord, TRPV1, Synaptic Transmission, sensory afferent neurons, capsaicin, synaptophysin, noxious stimuli, amygdala, periaqueductal gray, TRPV1 mRNA, tetrodotoxin, vanilloids, eicosanoids, (PKC) activation, PIP2, mEPSCs, TRPV1 channels, PKC stimulation, hippocampal neurons, presynaptic dopamine receptors, EPSC amplitude, endovanilloids, dopaminergic neurons, GABAergic transmission, nociceptive responses, neurohypophysis, capsazepine, PLC signaling
Abstract: Transient Receptor Potential Vanilloid Type 1 is a prominent “pain” receptor expressed in sensory afferent neurons. TRPV1 on peripheral nerve terminals detects a variety of noxious stimuli generated at sites of injury and inflammation, and in turn, drives the excitation and sensitization of C-fiber neurons. Significantly, TRPV1 is also located on the central terminals of sensory neurons projecting to the spinal cord and brainstem. These TRPV1 channels appear to stimulate the secretion of glutamate. Further, TRPV1 is expressed diffusely in the brain and there is emerging evidence for TRPV1 modulating transmission at various brain synapses. Here we discuss our current understanding of the potential roles for TRPV1 in synaptic transmission.
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Cite this article as:
A. Matta Jose and P. Ahern Gerard, TRPV1 and Synaptic Transmission, Current Pharmaceutical Biotechnology 2011; 12 (1) . https://dx.doi.org/10.2174/138920111793937925
DOI https://dx.doi.org/10.2174/138920111793937925 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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