Use of the Adamantane Structure in Medicinal Chemistry

Title: Use of the Adamantane Structure in Medicinal Chemistry

Volume: 17 Issue: 26

Author(s): Guy Lamoureux and Graciela Artavia

Affiliation:

Keywords: Adamantane, hydrophobic effects, ion channels, rigid scaffold

Abstract: This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.

Cite this article as:

Lamoureux Guy and Artavia Graciela, Use of the Adamantane Structure in Medicinal Chemistry, Current Medicinal Chemistry 2010; 17 (26) . https://dx.doi.org/10.2174/092986710792065027